Erythromycin Mode Of Action Facts

Erythromycin Mode Of Action Resource

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What is the mode of action of antimicrobial activity of? Streptomycin ii. Chloramphenicol iii. Erythromycin

raerae_2001 replied: "all 3 bind bacterial robosomes and prevent protein translation. strep binds in the 30S subunit and the other two bind in the 50S subunit."

Describe the mode of action of each of the following antibiotics? And explain what effect each one may have on host cells. Give an example of an organism that would be effectively treated for each drug. Penicillin Indinavir Erythromycin polymyxin B

Dr. Chris replied: "penicillin - synthesis of cell wall - penicillin binding protein, inhibits cross linkin of peptidoglycan (Staphylococcus) Indinavir - it's a protease inhibitor, an antiviral (was used in HIV infections) erythromycin - binds to ribosome blocking peptide synthesis (a wide spectrum for example Treponema sp.) Polymyxin B - causes membrane leakage, it's a cationic detergent (active on gram negative bacteria like Salmonella)"

Mode of action of these antibiotics:? What is the mode of action of these antibiotics on Bacillus subtilis? Ampicillin Erythromycin Leucomycin Chlorophenocol Any help would be greatly appreciated, thanks in advance =)

Emerson replied: "Ampicillin: The bactericidal activity of Ampicillin results from the inhibition of cell wall synthesis and is mediated through Ampicillin binding to penicillin binding proteins (PBPs). Ampicillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases. Erythromycin: Acts by penetrating the bacterial cell membrane and reversibly binding to the 50 S subunit of bacterial ribosomes or near the P or donor site so that binding of tRNA (transfer RNA) to the donor site is blocked. Leucomycin: Inhibition of peptidyltransferase as well as antimicrobial activity increased with the length of the aliphatic side chain in 4''-position of mycarose and decreased with acylation in 3-position of the lactone ring. Inhibition of peptidyltransferase is paralleled by inhibition of acceptor substrate binding. Chlorophenocol: The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle."

Alan V replied: "ampicillin is a pencillin derivative that acts to inihbit the final cross-linking event in peptidoglycan sysnthesis. Because Bacillus is gram positive it is preferentially killed this way: without peptidoglycan ded in the outer cell wall, the cell loses integrity and the "osmotic" potential of the contents within cause the cell to lyse. sorry i'm not too familiar with the others"

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